QUALITY BY DESIGN APPROACH FOR OPTIMIZATION AND DEVELOPMENT OF ORODISPERSIBLE FILMS OF LORNOXICAM INCLUSION COMPLEXES
نویسندگان
چکیده
Lornoxicam is a non-steroidal anti-inflammatory drug, indicated in the treatment of osteoarthritis and rheumatoid arthritis. poor water-soluble drug hence possesses dissolution limited bioavailability. The aim current research work was to develop characterize orodispersible films enhance its bioavailability by employing Quality-by-Design (QbD) approach. Solvent casting method used formulate mouth dissolving films. Three formulation factors viz. amount polymer, PEG 400 type polymer were varied at different levels. responses selected disintegration time percent dissolved after 5mins. Under response surface methodology, historical data design employed perform statistical analysis using Design Expert software. developed found have good elasticity, folding endurance favorable tensile strength. be 9 17 seconds 5 minutes 49 95%. results ANOVA elucidated that there significant effect all on (p
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ژورنال
عنوان ژورنال: Hacettepe University Journal of the Faculty of Pharmacy
سال: 2022
ISSN: ['1300-0608']
DOI: https://doi.org/10.52794/hujpharm.1072840